Researchers in Scotland, UK, have discovered how normal pigment cells move during embryo development--findings that could lead to a new treatment for malignant melanoma.
The researchers uncovered a basic mechanism of how normal pigment cells- melanoblasts--move during embryo development, which is thought to be an analogy for how mature pigment cells might acquire the ability to move when a person has melanoma. During embryonic development, melanoblasts migrate through the developing skin using long protrusions. The researchers found that, without the Rac1 protein, mouse melanoblasts lose these 'legs' and slow down their movement dramatically (Developmental Cell, doi: …
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